TY - JOUR
T1 - Transmission of second-hand smoke sensitivity and smoking attitude in a family
AU - Tarnoki, David Laszlo
AU - Tarnoki, Adam Domonkos
AU - Littvay, Levente
AU - Lazar, Zsofia
AU - Karlinger, Kinga
AU - Molnar, Andrea Agnes
AU - Melicher, Dora
AU - Garami, Zsolt
AU - Berczi, Viktor
AU - Horvath, Ildiko
N1 - Publisher Copyright:
© 2014, Institute of Agricultural Medicine. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Introduction and objective. The role of genetic factors in nicotine dependence is well understood, but no information is available on the inheritability of second-hand smoke (SHS) exposure sensitivity and their co-variance.Materials and methods. 186 adult same-gender pairs of twin (146 monozygotic, 40 dizygotic; 44±17 years±SD) completed a questionnaire.Results. The model showed a significant role of unshared environmental factors influencing the co-variance between smoking habit and SHS sensitivity (re=-0.191, 95% CI, -0.316 to -0.056, or the total phenotypic correlation of rph=-0.406, p<0.001) without evidence for genetic covariation. Age, gender and country-adjusted analysis indicated 51.5% heritability for smoking habit (95% confidence interval/CI/, 6.2 to 89.8%), 49.7% for SHS sensitivity (95%CI, 19.1–72.0%), 35.5% for general opinions on SHS exposure in restaurants/cafés (95%CI, 10.7–58.6%), and 16.9% in pubs/bars (95%CI, 0.0–49.0%).Conclusions. The co-variance between SHS sensitivity and smoking habits is driven mainly by the unshared environment. SHS sensitivity is moderately inheritable. The considerable influence of environmental factors on general opinions on SHS exposure in designated indoor public venues emphasizes the importance of smoking bans and health behaviour interventions at the individual level in developing an anti-smoking attitude.
AB - Introduction and objective. The role of genetic factors in nicotine dependence is well understood, but no information is available on the inheritability of second-hand smoke (SHS) exposure sensitivity and their co-variance.Materials and methods. 186 adult same-gender pairs of twin (146 monozygotic, 40 dizygotic; 44±17 years±SD) completed a questionnaire.Results. The model showed a significant role of unshared environmental factors influencing the co-variance between smoking habit and SHS sensitivity (re=-0.191, 95% CI, -0.316 to -0.056, or the total phenotypic correlation of rph=-0.406, p<0.001) without evidence for genetic covariation. Age, gender and country-adjusted analysis indicated 51.5% heritability for smoking habit (95% confidence interval/CI/, 6.2 to 89.8%), 49.7% for SHS sensitivity (95%CI, 19.1–72.0%), 35.5% for general opinions on SHS exposure in restaurants/cafés (95%CI, 10.7–58.6%), and 16.9% in pubs/bars (95%CI, 0.0–49.0%).Conclusions. The co-variance between SHS sensitivity and smoking habits is driven mainly by the unshared environment. SHS sensitivity is moderately inheritable. The considerable influence of environmental factors on general opinions on SHS exposure in designated indoor public venues emphasizes the importance of smoking bans and health behaviour interventions at the individual level in developing an anti-smoking attitude.
KW - Environmental exposure
KW - Genetics
KW - Heritability
KW - Smoking habits
KW - Tobacco smoking
UR - http://www.scopus.com/inward/record.url?scp=84915815356&partnerID=8YFLogxK
U2 - 10.5604/12321966.1129931
DO - 10.5604/12321966.1129931
M3 - Article
C2 - 25528918
AN - SCOPUS:84915815356
SN - 1232-1966
VL - 21
SP - 771
EP - 775
JO - Annals of Agricultural and Environmental Medicine
JF - Annals of Agricultural and Environmental Medicine
IS - 4
ER -
