The impact of cellular networks on disease comorbidity

Juyong Park*, Deok Sun Lee, Nicholas A. Christakis, Albert László Barabási

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract (may include machine translation)

The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease - gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms.

Original languageEnglish
Article number262
JournalMolecular Systems Biology
Volume5
DOIs
StatePublished - 20 Jan 2009
Externally publishedYes

Keywords

  • Cellular networks
  • Comorbidity
  • Database
  • Population-level statistics

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