Interactome networks and human disease

Marc Vidal; Michael E. Cusick; Albert László Barabási

doi:10.1016/j.cell.2011.02.016

Interactome networks and human disease

Marc Vidal^*
, Michael E. Cusick
, Albert László Barabási

^*Corresponding author for this work

Dana-Farber Cancer Institute
Harvard University
Northeastern University

Research output: Contribution to journal › Review Article › peer-review

Abstract (may include machine translation)

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

Original language	English
Pages (from-to)	986-998
Number of pages	13
Journal	Cell
Volume	144
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2011.02.016
State	Published - 18 Mar 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.cell.2011.02.016

Cite this

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title = "Interactome networks and human disease",

abstract = "Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.",

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AU - Vidal, Marc

AU - Cusick, Michael E.

AU - Barabási, Albert László

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Y1 - 2011/3/18

N2 - Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

AB - Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

UR - https://www.scopus.com/pages/publications/79952674000

U2 - 10.1016/j.cell.2011.02.016

DO - 10.1016/j.cell.2011.02.016

M3 - Review Article

C2 - 21414488

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SN - 0092-8674

VL - 144

SP - 986

EP - 998

JO - Cell

JF - Cell

IS - 6

ER -

Interactome networks and human disease

Abstract (may include machine translation)

UN SDGs

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