Interactome networks and human disease

Marc Vidal*, Michael E. Cusick, Albert László Barabási

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

Abstract (may include machine translation)

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

Original languageEnglish
Pages (from-to)986-998
Number of pages13
JournalCell
Volume144
Issue number6
DOIs
StatePublished - 18 Mar 2011
Externally publishedYes

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