Heritability of the femoral intima media thickness

Bence Fejer; Adam D. Tarnoki; David L. Tarnoki; Pierleone Lucatelli; Levente Littvay; Pal Maurovich-Horvat; Adam L. Jermendy; Attila Kovacs; Erika Godor; Corrado Fagnani; Maria A. Stazi; Andrea A. Molnar; Fabrizio Fanelli; Carlo Cirelli; Filippo Farina; Claudio Baracchini; Giorgio Meneghetti; Giacomo Pucci; Gyorgy Jermendy; Bela Merkely; Giuseppe Schillaci; Emanuela Medda

doi:10.1016/j.ejim.2017.02.019

Heritability of the femoral intima media thickness

Bence Fejer, Adam D. Tarnoki, David L. Tarnoki, Pierleone Lucatelli, Levente Littvay, Pal Maurovich-Horvat, Adam L. Jermendy, Attila Kovacs, Erika Godor, Corrado Fagnani, Maria A. Stazi, Andrea A. Molnar, Fabrizio Fanelli, Carlo Cirelli, Filippo Farina, Claudio Baracchini, Giorgio Meneghetti, Giacomo Pucci, Gyorgy Jermendy, Bela MerkelyGiuseppe Schillaci, Emanuela Medda

Department of Political Science

Research output: Contribution to journal › Article › peer-review

Abstract (may include machine translation)

Background The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease.

Materials and methods 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers.

Results Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure.

Conclusions Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

Original language	English
Pages (from-to)	44-48
Number of pages	5
Journal	European Journal of Internal Medicine
Volume	41
DOIs	https://doi.org/10.1016/j.ejim.2017.02.019
State	Published - 2017

Keywords

Atherosclerosis
Cardiovascular risk
Circulation
Gene
Twins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejim.2017.02.019

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Fejer, B., Tarnoki, A. D., Tarnoki, D. L., Lucatelli, P., Littvay, L., Maurovich-Horvat, P., Jermendy, A. L., Kovacs, A., Godor, E., Fagnani, C., Stazi, M. A., Molnar, A. A., Fanelli, F., Cirelli, C., Farina, F., Baracchini, C., Meneghetti, G., Pucci, G., Jermendy, G., ... Medda, E. (2017). Heritability of the femoral intima media thickness. European Journal of Internal Medicine, 41, 44-48. https://doi.org/10.1016/j.ejim.2017.02.019

@article{ecb4e5a998854846a4bf4d99a4eb7a8b,

title = "Heritability of the femoral intima media thickness",

abstract = "Background The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. Materials and methods 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. Results Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure. Conclusions Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.",

keywords = "Atherosclerosis, Cardiovascular risk, Circulation, Gene, Twins",

author = "Bence Fejer and Tarnoki, {Adam D.} and Tarnoki, {David L.} and Pierleone Lucatelli and Levente Littvay and Pal Maurovich-Horvat and Jermendy, {Adam L.} and Attila Kovacs and Erika Godor and Corrado Fagnani and Stazi, {Maria A.} and Molnar, {Andrea A.} and Fabrizio Fanelli and Carlo Cirelli and Filippo Farina and Claudio Baracchini and Giorgio Meneghetti and Giacomo Pucci and Gyorgy Jermendy and Bela Merkely and Giuseppe Schillaci and Emanuela Medda",

note = "Publisher Copyright: {\textcopyright} 2017 European Federation of Internal Medicine",

year = "2017",

doi = "10.1016/j.ejim.2017.02.019",

language = "English",

volume = "41",

pages = "44--48",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

}

Fejer, B, Tarnoki, AD, Tarnoki, DL, Lucatelli, P, Littvay, L, Maurovich-Horvat, P, Jermendy, AL, Kovacs, A, Godor, E, Fagnani, C, Stazi, MA, Molnar, AA, Fanelli, F, Cirelli, C, Farina, F, Baracchini, C, Meneghetti, G, Pucci, G, Jermendy, G, Merkely, B, Schillaci, G & Medda, E 2017, 'Heritability of the femoral intima media thickness', European Journal of Internal Medicine, vol. 41, pp. 44-48. https://doi.org/10.1016/j.ejim.2017.02.019

TY - JOUR

T1 - Heritability of the femoral intima media thickness

AU - Fejer, Bence

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Lucatelli, Pierleone

AU - Littvay, Levente

AU - Maurovich-Horvat, Pal

AU - Jermendy, Adam L.

AU - Kovacs, Attila

AU - Godor, Erika

AU - Fagnani, Corrado

AU - Stazi, Maria A.

AU - Molnar, Andrea A.

AU - Fanelli, Fabrizio

AU - Cirelli, Carlo

AU - Farina, Filippo

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Pucci, Giacomo

AU - Jermendy, Gyorgy

AU - Merkely, Bela

AU - Schillaci, Giuseppe

AU - Medda, Emanuela

PY - 2017

Y1 - 2017

N2 - Background The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. Materials and methods 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. Results Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure. Conclusions Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

AB - Background The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. Materials and methods 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. Results Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%–65.2%) and 47.2% (95% CI, 31.4%–62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%–78.5%) and 52.8% (95% CI, 37.2%–68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure. Conclusions Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

KW - Atherosclerosis

KW - Cardiovascular risk

KW - Circulation

KW - Gene

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=85013395180&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2017.02.019

DO - 10.1016/j.ejim.2017.02.019

M3 - Article

C2 - 28237540

AN - SCOPUS:85013395180

SN - 0953-6205

VL - 41

SP - 44

EP - 48

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

ER -

Heritability of the femoral intima media thickness

Abstract (may include machine translation)

Keywords

UN SDGs

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