TY - JOUR
T1 - Genetic covariance between central corneal thickness and anterior chamber volume
T2 - A Hungarian twin study
AU - Toth, Georgina Zsofia
AU - Racz, Adel
AU - Tarnoki, Adam Domonkos
AU - Tarnoki, David Laszlo
AU - Szekelyhidi, Zita
AU - Littvay, Levente
AU - Suveges, Ildiko
AU - Nemeth, Janos
AU - Nagy, Zoltan Zsolt
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2014/10/6
Y1 - 2014/10/6
N2 - Background: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). Methods: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry. Results: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p <.05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. Conclusion: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.
AB - Background: Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT). Methods: Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry. Results: Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p <.05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model. Conclusion: These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.
KW - anterior chamber depth
KW - anterior segment
KW - genetics
KW - glaucoma
KW - heritability
KW - keratometry
UR - http://www.scopus.com/inward/record.url?scp=84914692236&partnerID=8YFLogxK
U2 - 10.1017/thg.2014.54
DO - 10.1017/thg.2014.54
M3 - Article
C2 - 25300003
AN - SCOPUS:84914692236
SN - 1832-4274
VL - 17
SP - 397
EP - 404
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 5
ER -