TY - JOUR
T1 - Development of cross-orientation suppression and size tuning and the role of experience
AU - Popović, Marjena
AU - Stacy, Andrea K.
AU - Kang, Mihwa
AU - Nanu, Roshan
AU - Oettgen, Charlotte E.
AU - Wise, Derek L.
AU - Fiser, József
AU - Van Hooser, Stephen D.
N1 - Publisher Copyright:
© 2018 the authors.
PY - 2018/3/14
Y1 - 2018/3/14
N2 - Many sensory neural circuits exhibit response normalization, which occurs when the response of a neuron to a combination of multiple stimuli is less than the sum of the responses to the individual stimuli presented alone. In the visual cortex, normalization takes the forms of cross-orientation suppression and surround suppression. At the onset of visual experience, visual circuits are partially developed and exhibit some mature features such as orientation selectivity, but it is unknown whether cross-orientation suppression is present at the onset of visual experience or requires visual experience for its emergence. We characterized the development of normalization and its dependence on visual experience in female ferrets. Visual experience was varied across the following three conditions: typical rearing, dark rearing, and dark rearing with daily exposure to simple sinusoidal gratings (14–16 h total). Cross-orientation suppression and surround suppression were noted in the earliest observations, and did not vary considerably with experience. We also observed evidence of continued maturation of receptive field properties in the second month of visual experience: substantial length summation was observed only in the oldest animals(postnatal day90); evokedfiringratesweregreatlyincreasedinolderanimals; anddirectionselectivityrequiredexperience, butdeclined slightly in older animals. These results constrain the space of possible circuit implementations of these features.
AB - Many sensory neural circuits exhibit response normalization, which occurs when the response of a neuron to a combination of multiple stimuli is less than the sum of the responses to the individual stimuli presented alone. In the visual cortex, normalization takes the forms of cross-orientation suppression and surround suppression. At the onset of visual experience, visual circuits are partially developed and exhibit some mature features such as orientation selectivity, but it is unknown whether cross-orientation suppression is present at the onset of visual experience or requires visual experience for its emergence. We characterized the development of normalization and its dependence on visual experience in female ferrets. Visual experience was varied across the following three conditions: typical rearing, dark rearing, and dark rearing with daily exposure to simple sinusoidal gratings (14–16 h total). Cross-orientation suppression and surround suppression were noted in the earliest observations, and did not vary considerably with experience. We also observed evidence of continued maturation of receptive field properties in the second month of visual experience: substantial length summation was observed only in the oldest animals(postnatal day90); evokedfiringratesweregreatlyincreasedinolderanimals; anddirectionselectivityrequiredexperience, butdeclined slightly in older animals. These results constrain the space of possible circuit implementations of these features.
KW - Development
KW - Divisive normalization
KW - Nature
KW - Nurture
KW - Sensory cortex
KW - Vision
UR - http://www.scopus.com/inward/record.url?scp=85043785338&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2886-17.2018
DO - 10.1523/JNEUROSCI.2886-17.2018
M3 - Article
C2 - 29431651
AN - SCOPUS:85043785338
SN - 0270-6474
VL - 38
SP - 2656
EP - 2670
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 11
ER -