Determination of atomic local order in thyroid hormones by extended x-ray absorption fine structure {EXAFS} for radiation dose estimates

Brian R. Orton, Diana Vorsatz, Dan Macovei

Research output: Contribution to journalConference articlepeer-review

Abstract (may include machine translation)

Dosimetry from 125I emitting Auger electrons in the follicles of the thyroid will improve when their complete interaction with the molecular structure about the Auger emitting atoms is known to Angstrom distances. Extended x-ray absorption fine structure (EXAFS) can provide this information. EXAFS experiments gave intermolecular and intramolecular distance for pure solid L-thyroxine (T4) (C15H11I4NO4) using a model based on crystalline T4 hydrochloride monohydrate (C15H11I4NO4HCl.H2O). For a solution of L-thyroxine the structure consists of the intramolecular distances found for T4 and an additional shell of four carbon atoms distances of 2.01 angstroms. Atomic density functions from Fourier transformed EXAFS measurements are suitable for estimating very short range interactions of Auger electrons in thyroid thyroglobulin over a radial distance of 7.71 angstroms. Examination of density functions provided a plausible argument for the difference in biological effect between 131I and 125I in the thyroid.

Original languageEnglish
Pages (from-to)895-899
Number of pages5
JournalActa Oncologica
Volume35
Issue number7
DOIs
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1995 3rd International Symposium on Biophysical Aspects of Auger Processes - Lund, Swed
Duration: 24 Aug 199525 Aug 1995

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