TY - JOUR
T1 - Decoding the Foodome
T2 - Molecular Networks Connecting Diet and Health
AU - Menichetti, Giulia
AU - Barabási, Albert László
AU - Loscalzo, Joseph
N1 - Publisher Copyright:
Copyright © 2024 by the author(s).
PY - 2024/8/29
Y1 - 2024/8/29
N2 - Diet, a modifiable risk factor, plays a pivotal role in most diseases, from cardiovascular disease to type 2 diabetes mellitus, cancer, and obesity. However, our understanding of the mechanistic role of the chemical compounds found in food remains incomplete. In this review, we explore the “dark matter” of nutrition, going beyond the macro- and micronutrients documented by national databases to unveil the exceptional chemical diversity of food composition. We also discuss the need to explore the impact of each compound in the presence of associated chemicals and relevant food sources and describe the tools that will allow us to do so. Finally, we discuss the role of network medicine in understanding the mechanism of action of each food molecule. Overall, we illustrate the important role of network science and artificial intelligence in our ability to reveal nutrition’s multifaceted role in health and disease.
AB - Diet, a modifiable risk factor, plays a pivotal role in most diseases, from cardiovascular disease to type 2 diabetes mellitus, cancer, and obesity. However, our understanding of the mechanistic role of the chemical compounds found in food remains incomplete. In this review, we explore the “dark matter” of nutrition, going beyond the macro- and micronutrients documented by national databases to unveil the exceptional chemical diversity of food composition. We also discuss the need to explore the impact of each compound in the presence of associated chemicals and relevant food sources and describe the tools that will allow us to do so. Finally, we discuss the role of network medicine in understanding the mechanism of action of each food molecule. Overall, we illustrate the important role of network science and artificial intelligence in our ability to reveal nutrition’s multifaceted role in health and disease.
KW - artificial intelligence
KW - complexity
KW - machine learning
KW - network medicine
KW - network science
KW - nutrition
KW - systems pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85203116917&partnerID=8YFLogxK
U2 - 10.1146/annurev-nutr-062322-030557
DO - 10.1146/annurev-nutr-062322-030557
M3 - Review Article
C2 - 39207880
AN - SCOPUS:85203116917
SN - 0199-9885
VL - 44
SP - 257
EP - 288
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
IS - 1
ER -