Chronic hepatitis C virus infection associated with autonomic dysfunction

János Osztovits; Tamás Horváth; Margit Abonyi; Tamás Tóth; Zsolt Visnyei; Gabriella Bekö; Tímea Csák; Péter László Lakatos; Levente Littvay; János Fehér; Péter Kempler; Márk Kollai; Ferenc Szalay

doi:10.1111/j.1478-3231.2009.02075.x

Chronic hepatitis C virus infection associated with autonomic dysfunction

János Osztovits^*, Tamás Horváth, Margit Abonyi, Tamás Tóth, Zsolt Visnyei, Gabriella Bekö, Tímea Csák, Péter László Lakatos, Levente Littvay, János Fehér, Péter Kempler, Márk Kollai, Ferenc Szalay

^*Corresponding author for this work

Department of Political Science

Semmelweis University

Research output: Contribution to journal › Article › peer-review

Abstract (may include machine translation)

Background: Impaired autonomic function has been described in patients with chronic liver diseases from different aetiologies, and has proven to be a poor prognostic indicator. To date, it is not known how chronic hepatitis C virus (HCV) infection affects the autonomic nervous system.

Aims: In the present study, we compared cardiovagal autonomic function in patients with chronic HCV infection and healthy controls and examined the relation between autonomic function and serum levels of aminotransferases, HCV RNA, cryoglobulins, albumin and glucose.

Methods: Autonomic function was assessed in 45 treatment-naïve patients with chronic HCV infection and in 40 healthy controls by determining spontaneous baroreflex sensitivity (BRS) and heart rate variability (HRV) indices. The R-R interval was determined by electrocardiogramrecording; continuous radial artery pressure was monitored simultaneously by applanation tonometry. Laboratory analyses and quantitative polymerase chain reaction for serum HCV RNA level were performed by standard procedures.

Results: BRS and HRV time and frequency domain indices were lower in patients with HCV infection compared with healthy controls [7.1±3.4 vs. 11.5±6.5 ms/mmHg for BRS, 168.5±160.9 vs. 370.7±349.4 ms² for low-frequency HRV (mean±SD); Po0.01]. Multivariate analysis showed that autonomic dysfunction in HCV-infected patients correlated with elevated alanine aminotransferase levels, but was not associated with serum HCV RNA levels and cryoglobulins.

Conclusion: Our results suggest that impaired autonomic function is caused by chronic HCV infection. Further studies are needed, however, to identify the underlying mechanisms.

Original language	English
Pages (from-to)	1473-1478
Number of pages	6
Journal	Liver International
Volume	29
Issue number	10
DOIs	https://doi.org/10.1111/j.1478-3231.2009.02075.x
State	Published - 2009

Keywords

Autonomic dysfunction
Extrahepatic manifestations
Hepatitis C virus
Neuropathy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1478-3231.2009.02075.x

Cite this

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title = "Chronic hepatitis C virus infection associated with autonomic dysfunction",

abstract = "Background: Impaired autonomic function has been described in patients with chronic liver diseases from different aetiologies, and has proven to be a poor prognostic indicator. To date, it is not known how chronic hepatitis C virus (HCV) infection affects the autonomic nervous system. Aims: In the present study, we compared cardiovagal autonomic function in patients with chronic HCV infection and healthy controls and examined the relation between autonomic function and serum levels of aminotransferases, HCV RNA, cryoglobulins, albumin and glucose. Methods: Autonomic function was assessed in 45 treatment-na{\"i}ve patients with chronic HCV infection and in 40 healthy controls by determining spontaneous baroreflex sensitivity (BRS) and heart rate variability (HRV) indices. The R-R interval was determined by electrocardiogramrecording; continuous radial artery pressure was monitored simultaneously by applanation tonometry. Laboratory analyses and quantitative polymerase chain reaction for serum HCV RNA level were performed by standard procedures. Results: BRS and HRV time and frequency domain indices were lower in patients with HCV infection compared with healthy controls [7.1±3.4 vs. 11.5±6.5 ms/mmHg for BRS, 168.5±160.9 vs. 370.7±349.4 ms2 for low-frequency HRV (mean±SD); Po0.01]. Multivariate analysis showed that autonomic dysfunction in HCV-infected patients correlated with elevated alanine aminotransferase levels, but was not associated with serum HCV RNA levels and cryoglobulins. Conclusion: Our results suggest that impaired autonomic function is caused by chronic HCV infection. Further studies are needed, however, to identify the underlying mechanisms.",

keywords = "Autonomic dysfunction, Extrahepatic manifestations, Hepatitis C virus, Neuropathy",

author = "J{\'a}nos Osztovits and Tam{\'a}s Horv{\'a}th and Margit Abonyi and Tam{\'a}s T{\'o}th and Zsolt Visnyei and Gabriella Bek{\"o} and T{\'i}mea Cs{\'a}k and Lakatos, {P{\'e}ter L{\'a}szl{\'o}} and Levente Littvay and J{\'a}nos Feh{\'e}r and P{\'e}ter Kempler and M{\'a}rk Kollai and Ferenc Szalay",

year = "2009",

doi = "10.1111/j.1478-3231.2009.02075.x",

language = "English",

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T1 - Chronic hepatitis C virus infection associated with autonomic dysfunction

AU - Osztovits, János

AU - Horváth, Tamás

AU - Abonyi, Margit

AU - Tóth, Tamás

AU - Visnyei, Zsolt

AU - Bekö, Gabriella

AU - Csák, Tímea

AU - Lakatos, Péter László

AU - Littvay, Levente

AU - Fehér, János

AU - Kempler, Péter

AU - Kollai, Márk

AU - Szalay, Ferenc

PY - 2009

Y1 - 2009

N2 - Background: Impaired autonomic function has been described in patients with chronic liver diseases from different aetiologies, and has proven to be a poor prognostic indicator. To date, it is not known how chronic hepatitis C virus (HCV) infection affects the autonomic nervous system. Aims: In the present study, we compared cardiovagal autonomic function in patients with chronic HCV infection and healthy controls and examined the relation between autonomic function and serum levels of aminotransferases, HCV RNA, cryoglobulins, albumin and glucose. Methods: Autonomic function was assessed in 45 treatment-naïve patients with chronic HCV infection and in 40 healthy controls by determining spontaneous baroreflex sensitivity (BRS) and heart rate variability (HRV) indices. The R-R interval was determined by electrocardiogramrecording; continuous radial artery pressure was monitored simultaneously by applanation tonometry. Laboratory analyses and quantitative polymerase chain reaction for serum HCV RNA level were performed by standard procedures. Results: BRS and HRV time and frequency domain indices were lower in patients with HCV infection compared with healthy controls [7.1±3.4 vs. 11.5±6.5 ms/mmHg for BRS, 168.5±160.9 vs. 370.7±349.4 ms2 for low-frequency HRV (mean±SD); Po0.01]. Multivariate analysis showed that autonomic dysfunction in HCV-infected patients correlated with elevated alanine aminotransferase levels, but was not associated with serum HCV RNA levels and cryoglobulins. Conclusion: Our results suggest that impaired autonomic function is caused by chronic HCV infection. Further studies are needed, however, to identify the underlying mechanisms.

AB - Background: Impaired autonomic function has been described in patients with chronic liver diseases from different aetiologies, and has proven to be a poor prognostic indicator. To date, it is not known how chronic hepatitis C virus (HCV) infection affects the autonomic nervous system. Aims: In the present study, we compared cardiovagal autonomic function in patients with chronic HCV infection and healthy controls and examined the relation between autonomic function and serum levels of aminotransferases, HCV RNA, cryoglobulins, albumin and glucose. Methods: Autonomic function was assessed in 45 treatment-naïve patients with chronic HCV infection and in 40 healthy controls by determining spontaneous baroreflex sensitivity (BRS) and heart rate variability (HRV) indices. The R-R interval was determined by electrocardiogramrecording; continuous radial artery pressure was monitored simultaneously by applanation tonometry. Laboratory analyses and quantitative polymerase chain reaction for serum HCV RNA level were performed by standard procedures. Results: BRS and HRV time and frequency domain indices were lower in patients with HCV infection compared with healthy controls [7.1±3.4 vs. 11.5±6.5 ms/mmHg for BRS, 168.5±160.9 vs. 370.7±349.4 ms2 for low-frequency HRV (mean±SD); Po0.01]. Multivariate analysis showed that autonomic dysfunction in HCV-infected patients correlated with elevated alanine aminotransferase levels, but was not associated with serum HCV RNA levels and cryoglobulins. Conclusion: Our results suggest that impaired autonomic function is caused by chronic HCV infection. Further studies are needed, however, to identify the underlying mechanisms.

KW - Autonomic dysfunction

KW - Extrahepatic manifestations

KW - Hepatitis C virus

KW - Neuropathy

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U2 - 10.1111/j.1478-3231.2009.02075.x

DO - 10.1111/j.1478-3231.2009.02075.x

M3 - Article

C2 - 19602137

AN - SCOPUS:73349101051

SN - 1478-3223

VL - 29

SP - 1473

EP - 1478

JO - Liver International

JF - Liver International

IS - 10

ER -

Chronic hepatitis C virus infection associated with autonomic dysfunction

Abstract (may include machine translation)

Keywords

UN SDGs

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